25-year-old Harry Kane, England captain and Tottenham striker has sustained a significant lateral ligament injury to his left ankle.
He suffered the injury in the Champions League quarter-final first leg on Tuesday as his side defeated their rivals – Manchester City – by one goal to nil.
Kane’s injury could keep him out for the remainder of the 2018-19 season.
Tottenham Spurs have also confirmed that England midfielder Dele Alli, 23, has also fractured his left hand during the same match against Manchester City.
A club statement released by Tottenham said that Dele Alli will be assessed before Saturday’s home Premier League contest against Huddersfield Town.
Scoring 24 goals for Tottenham this season, Kane slipped as substituted right after he slipped as he tried to block Fabian Delph’s clearance in the second half of the game.
And after Tuesday’s match, Tottenham Spurs’ manager Mauricio Pochettino said: “It’s a worry for us.
“We are going to miss him – maybe for the rest of the season. We hope it is not a big issue but there is not too much time to recover.”
Fourth in the premier league, two points behind rivals, and with half a dozen matches remaining, Tottenham has merited being in the top four, and for four years in a row. They are ahead of north London rivals – Arsenal, who are fifth in the league.
In 37 appearances for England, Harry Kane has scored 22 goals who are set to face the Netherlands in the last four ties of the Nations League on 6 June.
The winners of that match will face either Portugal or Switzerland in the tournament’s final match three days later.